性能参数

产品名称

Pyrazoloacridine

规格

5mg

货号

GOY-Y2584

 含量

>98.00%

CAS

99009-20-8

别名

N/A

化学名

N/A

分子式

C19H21N5O3

分子量

分子量 367.4

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment[1][2].

Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC50 values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells[1].Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro[2].Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer[2].Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells[2].Pyrazoloacridine (NSC 366140) induces apoptosis in P53-deficient Hep 3B human hepatoma cells[2]. Cell Cytotoxicity Assay[2] Cell Line: K562 Myeloid Leukemia Cells.

[1]. J S Sebolt, et al. Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro. Cancer Res. 1987 Aug 15;47(16):4299-304. [2]. A A Adjei, et al. Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II. Clin Cancer Res. 1998 Mar;4(3):683-91.

天青Ⅱ AR  邻二甲苯 for HPLC,≥96.0% (GC)

对氨基-N,N-二乙基苯胺硫酸盐 AR,98%  呫吨-9-羧酸 98%

俾斯麦棕Y Biological stain  (2,2,6,6-四甲基-3,5-庚二酮酸)钇 99%

邻甲酚酞络合剂 indicator  无水氯化钇 粉末,99.99% metals basis

邻甲酚酞络合剂 98%  亚硫酸锌 98%

一次性手套  氢氯二茂锆 95%

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