性能参数

产品名称

Macitentan-d4

规格

1mg

货号

GOY-Y2564

 含量

>98.00%

CAS

1258428-05-5

别名

N/A

化学名

N/A

分子式

C19H16Br2D4N6O4S

分子量

分子量 592.3

溶解度

DMSO: slightly soluble,Methanol: slightly, heated

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Macitentan-d4 is intended for use as an internal standard for the quantification of macitentan by GC- or LC-MS. Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively).1 Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells (HPASMCs; IC50 = 0.9 nM), contractions of isolated rat aortic rings (pA2 = 7.6 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB). Macitentan increases plasma ET-1 concentrations in normotensive rats and decreases mean arterial blood pressure in hypertensive DOCA-salt rats (ED50 = 1 mg/kg). Oral administration (30 mg/kg per day) prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension induced by monocrotaline . It also decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes induced by streptozotocin . Formulations containing macitentan have been used for the treatment of pulmonary arterial hypertension.2

|1. Iglarz, M., Binkert, C., Morrison, K., et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J. Pharmacol. Exp. Ther. 327(3), 736-745 (2008).|2. Lefaucheur, C., Loupy, A., and Zeevi, A. Complement-binding anti-HLA antibodies and kidney transplantation. N. Engl. J. Med. 370(1), 85-86 (2014).

N,N,N',N'-四甲基-1,3-丙二胺 99%  硫代硫酸钠 99%,无水级

N,N,N',N'-四甲基-1,3-丙二胺 97%  硫代硫酸钠 99.99% metals basis,无水

碘酸铵 99%  ?；堑ㄋ崮?95%

碘化铵 AR,99.0%  四氯化硒 99.5%

碘化铵 99.999% metals basis  六氟锑酸银 99%

碘化铋 98%  硒酸溶液 40%水溶液

Cefozopran hydrochloride (SCE-2787 hydrochloride)10mM*1mLinWater 50mg 100mg>98.00%Cas No. 113981-44-5C19H18ClN9O5S2

Cefoxitin (sodium salt)250mg 500mg 1g>98.00%Cas No. 33564-30-6C16H16N3O7S2 ? Na

Cefotetan (sodium salt)50mg 100mg 250mg>98.00%Cas No. 74356-00-6C17H15N7O8S4?2Na

Cefoperazone (sodium salt)1g 5g 10g>98.00%Cas No. 62893-20-3C25H26N9O8S2 ? Na

Ceftriaxone sodium salt (Disodium ceftriaxone)10mM*1mLinWater 100mg 500mg>98.00%Cas No. 74578-69-1C18H16N8Na2O7S3

Ceftizoxime10mM*1mLinDMSO 50mg 100mg>98.00%Cas No. 68401-81-0C13H13N5O5S2

Cefsulodin (sodium salt)250mg 500mg 1g>98.00%Cas No. 52152-93-9C22H19N4O8S2 ? Na