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Kinsenoside

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产品名称: Kinsenoside
产品型号: GOY-Y2555
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-04-28

简单介绍

KinsenosideDMF: 14 mg/ml,DMSO: 16 mg/ml,PBS (pH 7.2): 10 mg/ml


Kinsenoside  的详细介绍

性能参数

产品名称

Kinsenoside

规格

1mg 5mg 10mg

货号

GOY-Y2555

 含量

>95.00%

CAS

151870-74-5

别名

N/A

 

 

化学名

N/A

分子式

C10H16O8

分子量

分子量 264.2

溶解度

DMF: 14 mg/ml,DMSO: 16 mg/ml,PBS (pH 7.2): 10 mg/ml

储存条件

4°C, protect from light

General tips

 

用途

仅供科研

价格

电询

详细内容

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.

 

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