ICCB-19 hydrochloride
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产品名称:
ICCB-19 hydrochloride
产品型号:
GOY-Y2542
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-28
简单介绍
ICCB-19 hydrochlorideDMSO : 83.33 mg/mL (285.53 mM; Need ultrasonic)
ICCB-19 hydrochloride
的详细介绍
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性能参数
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产品名称
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ICCB-19 hydrochloride
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规格
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5 mg 10 mg 25 mg 50 mg 100 mg
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货号
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GOY-Y2542
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含量
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>99.00%
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CAS
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1803605-68-6
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别名
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N/A
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化学名
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N/A
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分子式
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C12H22ClN3OS
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分子量
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分子量 291.84
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溶解度
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DMSO : 83.33 mg/mL (285.53 mM; Need ultrasonic)
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储存条件
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4°C, protect from light
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins[1].
ICCB-19 inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM[1]. ICCB-19 has no effect on mTOR. ICCB-19 (10 μM) treatment of cells increases the levels of DsRed-FYVE dots and the lipid kinase activity of VPS34[1]. ICCB-19 (10 μM) promotes autophagy via K63-linked ubiquitination of beclin 1 mediated by E3 ubiquitin ligases cIAP1 and cIAP2 and the adaptor TRAF2[1]. ICCB-19 (10 μM) reduces the rapid activation of RIPK1 in complex I induced by TNF. Treatment with ICCB-19 increases recruitment of TRADD, HOIP, and A20, but not RIPK1, to complex I[1].
ICCB-19 reduces inflammatory responses in Tradd-/- mice. ICCB-19 reduces expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns[1].
[1]. Daichao Xu, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587(7832):133-138.
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