性能参数

产品名称

Hydroxyurea

规格

10mM (in 1mL DMSO) 10mg 50mg

货号

GOY-Y2538

 含量

>99.00%

CAS

127-07-1

别名

N/A

化学名

hydroxyurea

分子式

CH4N2O2

分子量

分子量 76.05

溶解度

≥ 3.7mg/mL in DMSO

储存条件

Store at 2-8°C

General tips

用途

仅供科研

价格

电询

详细内容

Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase.

Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases[1]. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro[2]. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages[3].

Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice[4].

4-乙烯基苯硼酸 96%  (R)-(+)-α-甲氧基-α-(三氟甲基) 99%

2-溴代苯丙酮 96%  5-甲基异噁唑-3-羧酸甲酯 98%

子种绿A Biological stain  D(+)松三糖，一水 99%

金胺O 80%,用于生物染色  D(+)松三糖，一水 分析标准品

金胺O Biological stain  粘液酸 98%

金胺O 90%，用于生物染色  1-萘乙酸甲酯 98%

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