性能参数

产品名称

Indibulin

规格

10mM*1mL in DMSO 5mg 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y2530

 含量

>98.00%

CAS

204205-90-3

别名

N/A

化学名

N/A

分子式

C22H16ClN3O2

分子量

分子量 389.83

溶解度

DMSO: 50 mg/mL (128.26 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Indibulin (ZIO 301) , an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1]. Tubulin[1]

Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM[1]. Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis[1]. Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells[1]. Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 cells

[1]. Kapoor S, et al. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8(1):12363.

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