Hispidol ((Z)-Hispidol)
如果您对该产品感兴趣的话,可以
产品名称:
Hispidol ((Z)-Hispidol)
产品型号:
GOY-Y2528
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-28
简单介绍
Hispidol ((Z)-Hispidol)DMSO : ≥ 100 mg/mL (393.33 mM)
Hispidol ((Z)-Hispidol)
的详细介绍
性能参数
|
产品名称
|
Hispidol ((Z)-Hispidol)
|
规格
|
1mg 5mg 10mg 50mg 100mg 200mg 500mg
|
货号
|
GOY-Y2528
|
含量
|
>98.00%
|
CAS
|
5786-54-9
|
别名
|
N/A
|
|
|
化学名
|
N/A
|
分子式
|
C15H10O4
|
分子量
|
分子量 254.24
|
溶解度
|
DMSO : ≥ 100 mg/mL (393.33 mM)
|
储存条件
|
Store at -20°C
|
General tips
|
|
用途
|
仅供科研
|
价格
|
电询
|
|
详细内容
|
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression[1].
The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner[1].
[1]. Kadayat TM, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017 Sep 8;137:575-597.
|
公司正在销售的产品:
3-(三氟甲氧基)苯酚 98% 2-羟基-5-甲氧基苯甲醛 98%
4-氨基-2-氯吡啶 98% 2-羟基-6-甲基烟酸 98%
2-氯-4-氰基吡啶 97% 3-己炔-2-酮 97%
1,3,5-苯**酸 98% 5-己烯-2-酮 98.5%
4-乙烯基吡啶 96% 六氯-1,3-丁二烯 分析标准品
L-谷氨酰胺 99% 六氯-1,3-丁二烯 97.0%
|
Chlorhexidine diacetate100mg>98.00%Cas No. 56-95-1C26H38Cl2N10O4
Chitosan (Deacetylated chitin)10g>98.00%Cas No. 9012-76-4(C6H13NO5)n
Chloroxine50mg>98.00%Cas No. 773-76-2C9H5Cl2NO
Chlorothalonil100 mg>98.00%Cas No. 1897-45-6C8Cl4N2
Chlorobutanol hemihydrate1 g>98.00%Cas No. 6001-64-5C4H7Cl3O.1/2H2O
Chlorobutanol100mg>98.00%Cas No. 57-15-8C4H7Cl3O
Cinchonidine500mg>98.00%Cas No. 485-71-2C19H22N2O
|