性能参数

产品名称

Irbesartan

规格

10mM (in 1mL DMSO) 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y2525

 含量

>98.00%

CAS

138402-11-6

别名

N/A

化学名

2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

分子式

C25H28N6O

分子量

分子量 428.53

溶解度

≥ 17.4mg/mL in DMSO, ≥ 11.49 mg/mL in EtOH with ultrasonic

储存条件

Store at RT

General tips

用途

仅供科研

价格

电询

详细内容

Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.Target: Angiotensin ReceptorIrbesartan treatment markedly induces the expression of the adipogenic marker gene adipose protein 2 (aP2) in 3T3-L1 cells in a concentration-dependent manner with EC50 of 3.5 μM and 3.3-fold induction at the concentration of 10 μM. Irbesartan (10 μM) markedly induces transcriptional activity of the peroxisome proliferator–activated receptor-γ (PPARγ) by 3.4-fold independent of its AT1 receptor blocking action. Pretreatment with Irbesartan (~10 μM) decreases angiotensin II-induced apoptosis in rat vascular smooth muscle cells by blocking angiotensin II internalization in a concentrationdependent manner. Oral administration of Irbesartan (1 mg/kg) reduces angiotensin II (AII)-induced hypertension, equipotent with losartan in conscious normotensive rats, markedly more active than losartan (10 mg/kg) in normotensive cynomolgus monkeys. Administration of Irbesartan (7 mg/kg/day) significantly prevents skeletal muscle apoptosis and muscle atrophy in rats with monocrotaline-induced congestive heart failure (CHF), which is involved with the decrease of TNFα level and attributed to AT1 receptor blocking.

鹰嘴豆芽素A 分析标准品  乙酰丙酮铪 97%

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醋酸棉酚 分析标准品，98%  8-羟基喹哪啶 98%

海带多糖  ≥96%(HPLC)  5-己炔酸 97%

胡椒碱 97%  六正丁基二锡 98%

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