性能参数

产品名称

GGTI298 Trifluoroacetate

规格

10mM (in 1mL DMSO) 1mg 5mg 10mg 25mg 50mg

货号

GOY-Y2519

 含量

>98.00%

CAS

Chemical Properties1217457-86-7

别名

N/A

化学名

N/A

分子式

C29H34F3N3O5S

分子量

分子量 593.66

溶解度

DMSO : 150 mg/mL (252.67 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 uM; little effect on Ha-Ras with IC50 of >20 uM.

RhoA inhibitor (GGTI298 Trifluoroacetate) significantly reduces cAMP agonist-stimulated apical K+ conductance[1]. Knockdown of DR4 abolishes NF-κB activation, leading to sensitization of DR5-dependent apoptosis induced by the combination of GGTI298 Trifluoroacetate and TRAIL. GGTI298 Trifluoroacetate/TRAIL activates NF-κB and inhibits Akt. Knockdown of DR5, prevents GGTI298/TRAIL-induced IκBα and p-Akt reduction, suggesting that DR5 mediates reduction of IκBα and p-Akt induced by GGTI298/TRAIL. In contrast, DR4 knockdown further facilitates GGTI298/TRAIL-induced p-Akt reduction[2].

The vivo mouse ileal loop experiments show fluid accumulation is reduced in a dose-dependent manner by TRAM-34, GGTI298 Trifluoroacetate, or H1152 when inject together with cholera toxin into the loop[1].

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