性能参数

产品名称

KRIBB11

规格

5mg 10mg 25mg 50mg 100mg

货号

GOY-Y2516

 含量

>98.00%

CAS

342639-96-7

别名

N/A

化学名

N/A

分子式

C13H12N6O2

分子量

分子量 284.27

溶解度

DMSO : ≥ 27 mg/mL (94.98 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM.

KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter[1]. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 uM, and an IC50 of 20-30 uM[2].

KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss[1].

刺槐豆胶  3-溴丙酮酸乙酯 90%

1-丁基吡啶盐酸盐 98%  4-硝基苯甲酸乙酯 99%

苄基**基氢氧化铵 25%水溶液  乙氧基乙炔,己烷溶液 40 wt%己烷溶液

苄基**基氢氧化铵 40%甲醇溶液  3-乙基甲苯 99%

1-乙基吡啶盐酸盐  98%  N-乙基苄胺 97%

1-乙基吡啶氢溴酸盐  99%  乙烯利  >90.0%(HPLC)

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Antitrypanosomal agent 1100mg>95.00%Cas No. 75144-12-6C11H14Cl3NO

Azadirachtin B1mg>95.00%Cas No. 106500-25-8C33H42O14

Bactenecin (bovine) (trifluoroacetate salt)1 mg>95.00%Cas No. N/AC63H118N24O13S2·XCF3COOH

β-Rubromycin1mg 5mg>95.00%Cas No. 27267-70-5C27H20O12