性能参数

产品名称

Importazole

规格

5mg 10mg 25mg 50mg 100mg

货号

GOY-Y2515

 含量

>98.00%

CAS

662163-81-7

别名

N/A

化学名

N/A

分子式

C20H22N4

分子量

分子量 318.42

溶解度

DMSO : ≥ 33 mg/mL (103.64 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β.

Importazole specifically blocks importin-β-mediated nuclear import both in Xenopus egg extracts and cultured cells, without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export. Importazole impairs the release of an importin-β cargo FRET probe and causes both predicted and novel defects in spindle assembly[1]. Importazole displays an IC50 of approximately 15 uM for inhibition of NFAT-GFP import. Importazole has an IC50 of approximately 22.5 uM in HeLa cells following treatment over a 24-hour period[1]. Importazole induces a dose-and time-dependent inhibition of myeloma cells growth. And the IC50 values of importazole on RPMI 8226 and NCI-H929 after 48 hours incubation are (4.43±0.41) and (4.78±0.35) umol/L, respectively. Treatment of RPMI 8226 and NCI-H929 cells with 8 umol/L importazole for 24 h could inhibit NF-κB import to nucleus and reduce its DNA binding activity[2].

3,4-二氨基甲苯 分析标准品  赤藓红B钠盐 85%

3,4-二氨基甲苯 99.5%  赤藓红B钠盐 Biological stain

3,5-二甲氧基苯甲酸甲酯 99%  2-乙基丁酸 99%

2,4,6-**基苯胺 98%  4-乙基吡啶 98%

对甲苯胺 AR,99.0%  4-硝基苯甲酸甲酯 99%

三(羟甲基)氨基甲烷 标准缓冲物质, ≥99.9% (titration)  2-乙基-1-丁醇 98%

Baloxavir marboxil10mM*1mL in DMSO 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 1985606-14-1C27H23F2N3O7S

Baloxavir1mg 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 1985605-59-1C24H19F2N3O4S

Avibactam sodium hydrate10mM*1mL in Water 2mg 5mg 10mg 50mg 100mg 200mg>98.00%Cas No. N/AC7H12N3NaO7S

AU123510mM*1mLinDMSO 2mg 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 1338780-86-1C17H19F3N2O

Purity: >95.00%