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IB-MECA

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产品名称: IB-MECA
产品型号: GOY-Y2513
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-04-28

简单介绍

IB-MECADMSO : ≥ 45 mg/mL (88.19 mM)


IB-MECA  的详细介绍

性能参数

产品名称

IB-MECA

规格

2mg 5mg 10mg 25mg 50mg

货号

GOY-Y2513

 含量

>98.00%

CAS

152918-18-8

别名

N/A

 

 

化学名

N/A

分子式

C18H19IN6O4

分子量

分子量 510.29

溶解度

DMSO : ≥ 45 mg/mL (88.19 mM)

储存条件

Store at -20°C

General tips

 

用途

仅供科研

价格

电询

详细内容

IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 uM. IC50 value: 0.11 uM (EC50) [3]Target: adenosine A3 receptorin vitro: IB-MECA has been shown to play important roles in cell proliferation and apoptosis in a variety of cancer cell lines. TheIB-MECA was capable of decreasing intracellular cyclic adenosine monophosphate (cAMP) that was the reason for the presence of functional A3 adenosine receptor on the cell lines. IB-MECA significantly reduced cell viability in a dose-dependent manner. IB-MECA, an A3AR agonist, inhibits the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostateIB-MECA was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 0.82 uM in OVCAR-3 cells. IB-MECA was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 1.2 uM in Caov-4 cells.in vivo: Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice.[2]

 

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