性能参数

产品名称

Iberdomide

规格

2mg 5mg 10mg 25mg 50mg

货号

GOY-Y2512

 含量

>98.00%

CAS

1323403-33-3

别名

N/A

化学名

N/A

分子式

C25H27N3O5

分子量

分子量 449.5

溶解度

DMSO : ≥ 30 mg/mL (66.74 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Iberdomide (CC-220) is a cereblon modulator with an IC50 of 60 nM.

Lenalidomide and pomalidomide, targeting cereblon, are immunomodulatory drugs that are clinically effective in the treatment of cancer, including newly diagnosed and relapsed multiple myeloma. Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC50s of 1 nM and 0.5 nM [1].

Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM)[1].

铋 99.999%,1-6mm  2,5-二氯甲苯 98.0%

铋 99.99%  3,5-二氯苄胺 97%

铋 99.9999%,1-6mm  2,6-二氯苯基乙酸 98%

铋标准溶液 1000μg/ml，溶剂：1.5 mol/L HNO3  2,5-二氯苯腈 97%

铋标准溶液 100mg/L，基体: 5％HNO3  3,4-二氯苯胺 98%

纳米铋粉 99.9% metals basis,40nm,球形  2,6-二氯苯磺酰氯 97%

AT-1305 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 211364-06-6C22H22BrN3O5

Artemotil (β-Arteether)10mM*1mLinDMSO 5mg 10mg 50mg 100mg>98.00%Cas No. 75887-54-6C17H28O5

Artemisone10mM*1mL in DMSO 5mg 10mg 50mg 100mg>98.00%Cas No. 255730-18-8C19H31NO6S

AVX 136162mg 5mg 10mg 50mg 100mg>98.00%Cas No. 900814-48-4C50H73Cl2N7O7

Azathramycin10mg 50mg 100mg 250mg 500mg>98.00%Cas No. 76801-85-9C37H70N2O12

Bay 41-4109 racemate1mg 5mg 10mg 50mg 100mg>98.00%Cas No. 298708-79-9C18H13ClF3N3O2