性能参数

产品名称

HJC0152 hydrochloride

规格

5mg 10mg 25mg 50mg 100mg

货号

GOY-Y2510

 含量

>98.00%

CAS

1420290-99-8

别名

N/A

化学名

N/A

分子式

C15H14Cl3N3O4

分子量

分子量 406.65

溶解度

DMSO : 6 mg/mL (14.75 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

HJC0152 hydrochloride is a signal transducers and activators of transcription 3 (STAT3) inhibitor.

HJC0152 hydrochloride (compound 11) significantly inhibits cell proliferation and induces apoptosis accompanying cellular morphological changes at concentrations of 1, 5, and 10 μM. Results show that treatment with 10 μM HJC0152 hydrochloride decreases the STAT3 promoter activity in MDA-MB-231 cells by approximately 32%, and increasing the dose of HJC0152 hydrochloride to 20 μM further decreases STAT3 promoter activity by 62% as compare with control. Total STAT3 is reduced after treatment with HJC0152 hydrochloride. HJC0152 hydrochloride induces cleaved caspase-3 and down regulates cyclin D1 in MDA-MB-231 cells[1].

Mice treated with 7.5 mg/kg of HJC0152 hydrochloride (compound 11) via ip show a better effect in inhibiting tumor growth. The growth of xenograft tumors in mice is significantly reduced by HJC0152 hydrochloride at a dose of 25 mg/kg. It is also noteworthy that HJC0152 hydrochloride does not show significant signs of toxicity at a dose of 75 mg/kg[1].

[1]. Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185.

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