性能参数

产品名称

GSK-3β inhibitor 3

规格

5 mg 10 mg 25 mg 50 mg 100 mg

货号

GOY-Y2508

 含量

>98.00%

CAS

1448990-73-5

别名

N/A

化学名

N/A

分子式

C18H14FNO2S

分子量

分子量 327.37

溶解度

DMSO : 250 mg/mL (763.66 mM; Need ultrasonic)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia[1].

GSK-3β inhibitor 3 (compound 4-3) (100 μM) inhibits GSK-3α activity by 87.3%[1].GSK-3β inhibitor 3 (6.25-100 μM; 24-48 h) dose-dependently inhibits the growth of NB4 and NB4-R1 cells[1].GSK-3β inhibitor 3 (12.5-100 μM; 24 h) significantly increases the percentage of apoptosis in a dose-dependent pattern in NB4 and NB4-R1 cells[1].

GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg/d; i.p. for 2 weeks) inhibits tumor growth of mice by 75.97% relative to vehicle control[1].GSK-3β inhibitor 3 (15 mg/kg; a single i.p.) shows long T1/2 of 14.2 h, high AUC values (AUClast=3503.42 ng/mL?h), and maximum concentration (Cmax=515 ng/mL) in mice[1].

1-萘甲腈 95%  二甲基苯基硅烷 98%

2-乙烯基萘 97%  2,6-二氟二苯甲酮 98%

4-叔丁基苯甲醛 97%  3,4-二氟二苯甲酮 98%

盐酸金霉素 USP级,≥80.0% (HPLC)   2,4-二硝基氟苯 99%（剧毒品）

硫酸庆大霉素 USP级  2,4-二硝基苯甲醚 98%

硫酸庆大霉素 potency: ≥590 μg Gentamicin per mg  邻苯二甲酸二庚酯 98+%

Artemisinic Acid10mg 25mg 50mg 100mg>98.00%Cas No. 80286-58-4C15H22O2

Aprepitant10mM (in 1mL DMSO) 5mg 25mg 100mg>98.00%Cas No. 170729-80-3C23H21F7N4O3

Aplaviroc hydrochloride1 mg 5 mg 10 mg 25 mg>98.00%Cas No. 461023-63-2C33H44ClN3O6

Bedaquiline10mM (in 1mL DMSO) 5mg 10mg 50mg>98.00%Cas No. 843663-66-1C31H29BrN2O

BAY-Y 31181mg 5mg 10mg 20mg>98.00%Cas No. 151213-16-0C20H21ClFN3O3