性能参数

产品名称

Gemcitabine elaidate

规格

5mg 10mg 50mg 100mg 200mg

货号

GOY-Y2503

 含量

>98.00%

CAS

210829-30-4

别名

N/A

化学名

N/A

分子式

C27H43F2N3O5

分子量

分子量 527.64

溶解度

DMSO: ≥ 26 mg/mL (49.28 mM); H2O: < 0.1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Gemcitabine elaidate(CP-4126; CO-101) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.IC50 value:Target: Gemcitabine analogUpon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Check for active clinical trials or closed clinical trials using this agent.

4-氯-2-硝基苯胺 分析标准品，99.7%（HPLC)  二十二烷 standard for GC，≥99.0% (GC)

2-氯-4-硝基苯胺 98%  二十二烷 99%

2,5-二甲基苯胺 97%  三十二烷 standard for GC, ≥98.0% (GC)

3,4-二氯苯胺 98%  双十烷基二甲基溴化铵 80% 水溶胶

3,4-二氯苯胺 分析标准品  2,6-二硝基酚 96%

邻硝基苯胺 99%  N,N-二甲基乙胺 99%

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