性能参数

产品名称

Forodesine hydrochloride

规格

1mg 5mg 10mg 25mg 50mg

货号

GOY-Y2502

 含量

>98.00%

CAS

284490-13-7

别名

N/A

化学名

N/A

分子式

C11H15ClN4O4

分子量

分子量 302.71

溶解度

H2O : ≥ 74.1 mg/mL (244.79 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Forodesine hydrochloride is a potent and oral purine nucleoside phosphorylase (PNP) inhibitor with IC50s ranging from 0.48 to 1.57 nM.

[1]. Homminga I, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90. [2]. Ogura M, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5. [3]. Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895. [4]. Yamauchi T, et al. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. Anticancer Res. 2014 Sep;34(9):4885-92.

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