性能参数

产品名称

Indirubin

规格

10mM (in 1mL DMSO) 5mg 25mg 100mg 250mg

货号

GOY-Y2423

 含量

>98.00%

CAS

Cas No. 479-41-4

别名

化学名

分子式

C16H10N2O2

分子量

分子量 262.26

溶解度

DMF: 1 mg/ml,DMSO: 1 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Interferon-γ is thought to be a member of the inflammatory cytokine family. Because of its augmentation of inflammatory reactions through biological activities. Indirubin, the active ingredient of Danggui Longhui Wan, has inhibitory effects on the production of interferon-γ.

In vitro: Indirubin exerted its inhibitory effects not only on interferon-γ production by human myelomonocytic HBL-38 cells but also on interferon-γ and interleukin-σ production by murine splenocytes with no influence on the proliferation of either cells [1].

In vivo: Because of Indirubin’s inhibitory activity on interferon-γ production, the authors further investigated the effects of indirubin on 2,4,6-trinitro-l-chlorobenzene-induced delayed-type hypersensitivity. When injected intraperitoneally, indirubin significantly inhibited the ear swelling of TNCB-elicited mice. Moreover,the amount of interferon-γ in the culture supernatants of elicited mouse lymphocytes was inhibited by indirubin treatment [1].

Clinical trials: Several clnical trials have been conducted to study the efficacy of indirubin for the treatments of psoriasis and Acute Promyeloid Leukemia .

硫代乙醇酸 GR,98%  氮化钛 99%，20nm

正戊醛 98%  氮化钛 99.5%,2-10 μm

正戊酸 standard for GC, ≥99.5% (GC)  碳化锆 50nm, 99%

正戊酸 CP,98%  碳化锆 99%,1μm

正戊酸 分析标准品  氧化铈 20nm 球形，99.5%

正戊酸  >99% (GC)  氧化镝 ≥99.99% metals basis

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