性能参数

产品名称

K-Ras(G12C) inhibitor 12

规格

10mM (in 1mL DMSO) 5mg 25mg

货号

GOY-Y2412

 含量

>98.00%

CAS

Cas No. 1469337-95-8

别名

化学名

1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one

分子式

C15H17ClIN3O3

分子量

分子量 449.67

溶解度

≥ 8.98mg/mL in DMSO with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of K-Ras(G12C) [1].

K-Ras is a GTPase and plays an important role in many signal transduction pathways. The mutation of K-Ras occurs in many cancers.

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of K-Ras(G12C). K-Ras(G12C) exhibited a slight preference for GTP. However, K-Ras(G12C) inhibitor 12 significantly reduced the affinity for GTP and led to the modification of K-Ras(G12C). Also, K-Ras(G12C) inhibitor 12 inhibited SOS-catalysed nucleotide exchange. In H1792 and H358 K-Ras(G12C)-mutant lung cancer cell lines, K-Ras(G12C) inhibitor 12 reduced the association of C-Raf and B-Raf with Ras. In H1792, H358, H23 and Calu-1 cell lines containing G12C mutations, K-Ras(G12C) inhibitor 12 decreased viability and induced apoptosis. K-Ras(G12C) inhibitor 12 exhibited EC50 value of 0.32 μM in H1792 cells. Also, the H1792 cells exhibited low levels of K-Ras GTP, which was consistent with the preference of K-Ras(G12C) inhibitor 12 to K-Ras GDP [1].

氧化铟 99.99% metals basis， <50 nm (TEM)  吡啶 Standard for GC,>99.9%(GC)

硝酸铟水合物  99.99% metals basis  吡啶 AR

硝酸铟水合物  99.9% metals basis  吡啶 for HPLC, ≥99.9%

硫酸铟 SP  吡啶 无水级

硫酸铟 无水,99.99% metals basis  吡啶 分析标准品

氢氧化铟  99.99% metals basis  吡啶 ACS

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