性能参数

产品名称

kb NB 142-70

规格

10mM (in 1mL DMSO) 10mg 50mg

货号

GOY-Y2411

 含量

>98.00%

CAS

Cas No. 1233533-04-4

别名

化学名

9-hydroxy-3,4-dihydro-2H-[1]benzothiolo[2,3-f][1,4]thiazepin-5-one

分子式

C11H9NO2S2

分子量

分子量 251.32

溶解度

≥ 12.9 mg/mL in DMSO, ≥ 8.05 mg/mL in EtOH with ultrasonic and warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.

kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also inhibits Ser916 phosphorylation of PKD1 (IC50, 2.2 ± 0.6 μM) in LNCaP cells. Moreover, kb NB 142-70 is cytotoxic against PC3 cells with an EC50 of 8.025 μM[1]. kb NB 142-70 (0-5 μM) concentration-dependently prevents ANG II-induced phosphorylation of HDAC4 at Ser246 and Ser632, HDAC5 at Ser259 and Ser498, and HDAC7 at Ser155 in IEC-18 cells. In addition, kb NB 142-70 (3.5 μM) also suppresses HDAC4, HDAC5, and HDAC7 phosphorylation in IEC-18 cells stimulated with ANG II for 0-240 min or with vasopressin, lysophosphatidic acid (LPA), or phorbol 12,13-dibutyrate (PDBu)[2].

氯化铟 98%  乙酰乙酸甲酯 CP，98%

氯化铟 99.99% metals basis  乙酰乙酸甲酯 GR，99.5%

氯化铟 99.995% metals basis  乙酰乙酸甲酯 Standard for GC, ≥99.5% (GC)

氧化铟 SP  4-甲基吡啶 98%

氧化铟 99.99% metals basis  3-甲基吡啶 99%

氧化铟 99.99% metals basis， <100 nm (TEM)  3-甲基吡啶 99.5%(GC)

CAY1050550mg 200mg>98.00%Cas No. 1218777-13-9C14H8FNO3S

Crosstide1mg 5mg>98.00%Cas No. 171783-05-4C48H77N17O17

eCF309500μg 1mg>98.00%Cas No. 2001571-40-8C18H21N7O3

Dihydromyricetin10mM (in 1mL DMSO)20mg>98.00%Cas No. 27200-12-0C15H12O8

Desmethylglycitein1mg 5mg>98.00%Cas No. 17817-31-1C15H10O5

Danthron (Dantron)10mM*1mLinDMSO100mg>98.00%Cas No. 117-10-2C14H8O4

CZC2483210mM (in 1mL DMSO)5mg>98.00%Cas No. 1159824-67-5C15H17FN6O2S