ISRIB (trans-isomer)
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产品名称:
ISRIB (trans-isomer)
产品型号:
GOY-Y2410
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-27
简单介绍
ISRIB (trans-isomer)≥ 8.96 mg/mL in DMSO with gentle warming
ISRIB (trans-isomer)
的详细介绍
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性能参数
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产品名称
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ISRIB (trans-isomer)
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规格
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10mM (in 1mL DMSO) 10mg 25mg
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货号
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GOY-Y2410
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含量
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>98.00%
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CAS
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Cas No. 1597403-47-8
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别名
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化学名
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N,N'-((1s,4s)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
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分子式
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C22H24Cl2N2O4
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分子量
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分子量 451.34
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溶解度
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≥ 8.96 mg/mL in DMSO with gentle warming
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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ISRIB (trans-isomer) is a potent inhibitor of the integrated stress response (ISR) [1].
Integrated stress response (ISR) is activated by diverse cellular conditions and rapidly reduces overall protein synthesis while enhancing translation of specific transcripts that support adaptive stress responses. The ISR is mediated by diverse stress-sensing kinases that phosphorylating serine 51 in eukaryotic translation initiation factor alpha (eIF2α) [2].
ISRIB (trans-isomer) is a potent ISR inhibitor. ISRIB reversed the effects of eIF2α phosphorylation with IC50 value of 5 nM. ISRIB inhibited production of endogenous ATF4 (a cAMP element binding transcription factor). In mouse embryonic fibroblasts (MEFs), ISRIB reversed the increase in the 80S monosomes at the expense of polyribosomes induced by endoplasmic reticulum (ER) stress. In ER-stressed cells, ISRIB reduced cell survival [1]. In stressed cells, ISRIB restored mRNA translation and inhibited stress granule (SG) formation induced by eIF2α phosphorylation [2]. ISRIB inhibited the interaction between eIF2B and eIF2 that located at the core of the ISR [3]. Also, ISRIB was an activator of eIF2B and stabilized activated eIF2B dimers [4].
In mice, ISRIB significantly increased hippocampus-dependent spatial and fear-associated learning [1].
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