性能参数

产品名称

HS-173

规格

10mM (in 1mL DMSO) 5mg 25mg

货号

GOY-Y2408

 含量

>98.00%

CAS

Cas No. 1276110-06-5

别名

化学名

分子式

C21H18N4O4S

分子量

分子量 422.46

溶解度

≥ 21.1mg/mL in DMSO

储存条件

Desiccate at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Phosphatidylinositol 3-kinase (PI3K) was first identified over 20 years ago as a lipid kinase associated with viral oncoproteins. PI3K signaling pathway regulates various cellular processes such as growth, cell cycle progression, apoptosis, migration, metabolism, and cytoskeleton rearrangement. HS-173 is a novel PI3K inhibitor.

In vitro: HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G2/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1a and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro [1].

In vivo: HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. These results suggest that HS-173 has potent anti-angiogenic activity in vivo [1].

Clinical trials: Currenlty no clinical data are available.

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