性能参数

产品名称

HO-3867

规格

10mM (in 1mL DMSO) 5mg 25mg

货号

GOY-Y2406

 含量

>98.00%

CAS

Cas No. 1172133-28-6

别名

化学名

(3E,5E)-3,5-bis(4-fluorobenzylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one

分子式

C28H30F2N2O2

分子量

分子量 464.55

溶解度

≥ 18.15mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

HO-3867 is a novel curcumin analog and a selective inhibitor of STAT3. [1]

STAT3 (signal transducer and activator of transcription 3) belongs to the STAT protein family. It mediates various gene expressions for numerous cellular functions, including cell growth, division and apoptosis.

HO-3867 selectively blocked STAT3 phosphorylation, transcription, and DNA binding without inhibiting other STATs proteins. It activated apoptosis in ovarian cancer cells and showed minimal toxicity to healthy cells. [2] HO-3867 also significantly inhibited the proliferation of serum-stimulated SMCs and elevated the phosphorylated and total levels of PTENs in SMCs. [3] By inducing cell cycle arrest and apoptosis, HO-3867 reduced the high levels of pSTAT3 Ser727 in endometrial cancer cells. [4]

In mice tumor xenograft, HO-3867 inhibited the tumor growth without toxic side effects, it also blocked PSTAT3/JAK1 and increased apoptotic marker cleaved Caspase 3/PARP. [2] [5] After rat carotid artery injury, HO-3867 inhibited neointima formation and upregulated PTEN expression. [3]

DL-焦谷氨酸 98%  总氯试纸 0-20ppm

CBZ-L-焦谷氨酸 98%  总硬度试纸 0-1000ppm

L-苯丙氨酸苄酯盐酸盐 98%  六价铬试纸 0-100ppm

N-邻苯二甲酰-L-苯丙氨酸 98%  总硬度试纸 0-240ppm

L-苯丙氨酸苄酯对甲苯磺酸盐 98%  测氯试纸（**液试纸） 20-2000ppm

L-丝氨酸 99%  银试纸 0-20g/L

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