性能参数

产品名称

Isoliquiritigenin

规格

10mM (in 1mL DMSO) 20mg

货号

GOY-Y2400

 含量

>98.00%

CAS

Cas No. 961-29-5

别名

化学名

(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

分子式

C15H12O4

分子量

分子量 256.25

溶解度

≥ 12.4mg/mL in DMSO

储存条件

General tips

用途

仅供科研

价格

电询

详细内容

Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM.

Isoliquiritigenin may prevent diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM[1]. Isoliquiritigenin (100 μM) markedly inhibits the hypoxia-induced prolonged TPS and TR90 of cardiomyocytes. Isoliquiritigenin significantly triggers AMPK Thr172 phosphorylation as compared with vehicle group. Isoliquiritigenin treatment also induces extracellular signal-regulated kinase (ERK) signaling pathway in the cardiomyocytes. Isoliquiritigenin treatment significantly decreases the intracellular ROS levels of isolated cardiomyocytes during hypoxia/reoxygenation[3]. Isoliquiritigenin not only downregulates IL-6 expression but also significantly decreases levels of phosphorylated ERK and STAT3 and can inhibit phosphorylation levels of ERK and STAT3 induced by recombinant human IL-6, which are critical signaling proteins in IL-6 signaling regulation networks[4].

Isoliquiritigenin shows concentration-dependent inhibition of the tonic contraction of mouse jejunum induced by various types of stimulants such as CCh (1 mM), KCl (60 mM) and BaCl2 (0.3 mM) with IC50 values of 4.96±1.97 mM, 4.03±1.34 mM and 3.70±0.58 mM, respectively[2]. Isoliquiritigenin exhibits significant anti-tumor activity in MM xenograft models and synergistically enhances the anti-myeloma activity of adriamycin[4].

Boc-3-(2-萘基)-D-丙氨酸 99%  四丙氧基硅烷 97%

BOC-N-甲基-D-丙氨酸 98%  甲基**氧基硅烷 98%

BOC-L-丙氨醇 98%  四甲氧基硅烷 98%

N-Boc-L-异亮氨醇  98.5%  硅酸四乙酯 99.999% metals basis

BOC-D-脯氨醇 98%  甲基三乙酰氧基硅烷 90%

BOC-D-环己基甘氨酸 98%  三乙基氯硅烷 98%

PI 8281mg 5mg 10mg>98.00%Cas No. 942289-87-4C19H18N2O3

PI3Kdelta inhibitor 1100mg 250mg 500mg>98.00%Cas No. 2242109-74-4C27H38N6O5S

PI3K-IN-6100mg 250mg 500mg>98.00%Cas No. 1842380-77-1C17H14Cl2FN9O

PI3Kγ inhibitor 15mg 10mg 50mg>98.00%Cas No. 1172118-03-4C32H26N8O2S

PI3-Kinase α Inhibitor 2 (hydrochloride)1mg 5mg 10mg>98.00%Cas No. 1188890-32-5C16H15N3O2S?2HCl

PX-866-17OH1mg 5mg 10mg>98.00%Cas No. 1012327-63-7C29H37NO8

PX-13-17OH1mg 5mg 10mg>98.00%Cas No. 884539-95-1C29H42N2O8