性能参数

产品名称

iMAC2

规格

10mg 50mg

货号

GOY-Y2399

 含量

>98.00%

CAS

Cas No. 335166-36-4

别名

化学名

3,6-dibromo-9-(2-fluoro-3-(piperazin-1-yl)propyl)-9H-carbazole

分子式

C19H20Br2FN3.2HCl

分子量

分子量 542.11

溶解度

Limited solubility

储存条件

Desiccate at RT

General tips

用途

仅供科研

价格

电询

详细内容

iMAC2 is the inhibitor of mitochondrial apoptosis-induced channel (MAC) with the IC50 value of 28 nM[1]. MAC is a putative cytochrome c release channel involved in the intrinsic apoptotic pathway. MAC has been associated with oligomeric, not monomeric, Bax[2]. By blocking MAC and suppressing cytochrome c release, iMAC2 suppressed the onset of apoptotic markers [1].

In vitro: In cultured apoptotic FL5.12 cells, pre-treatment with iMAC2 resulted in a normal volume and residual Annexin V/PI staining. iMAC2 reduced apoptosis by more than 50%. Pre-treatment with iMAC2 induced a significant protection at low micromolar levels (IC50 = 2.5 μM). Pre-incubation with iMAC2 and iMAC3 essentially eliminated the release of cytochrome c (P < 0.0001) while nanomolar levels of iMAC2 completely blocked the current flow through MAC. iMAC2 inhibited release of cytochrome c by Bid-induced Bax activation with the IC50 values of 0.68 μM [1].

BOC-N-甲基-L-丙氨酸 98%  铝箔袋 160*100 mm

N-Boc-L-缬氨醇 98%  二月桂酸二丁基锡 95%

BOC-L-色氨酸 98%  γ-缩水甘油醚氧丙基**氧基硅烷 97%

1-苄基D-谷氨酸酯 98%  六甲基二硅氧烷 99%

N-Boc-N'-三苯甲基-L-组氨酸 98%  六甲基二硅胺烷 AR，98%

BOC-L-丝氨酸甲酯  BR  甲基三乙氧基硅烷 98%

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