性能参数

产品名称

Kobe0065

规格

1mg

货号

GOY-Y2391

 含量

>98.00%

CAS

Cas No. 436133-68-5

别名

化学名

N-(3-chloro-4-methylphenyl)-2-(2,6-dinitro-4-(trifluoromethyl)phenyl)hydrazinecarbothioamide

分子式

C15H11ClF3N5O4S

分子量

分子量 449.79

溶解度

≥ 23.85mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Kobe0065 is a small-molecule inhibitor of Ras with Ki value of 46 μM for the binding of H-Ras.GTP to c-Raf-1 [1].

Kobe0065 is a compound screened out by an in silico screen method as a potent inhibitor of the Ras–Raf interaction. It showed favorite efficacy to inhibit the binding of M-Ras.GTP and H-Ras.GTP to the Ras-binding domain of c-Raf-1. Kobe0065 also dose-dependently inhibited the binding of H-RasG12V to c-Raf-1 in NIH 3T3 cells with a rough IC50 value of 10 μM. Besides that, 20 μM of Kobe0065 effectively suppressed the phosphorylation of down-stream kinases of Raf, including MEK and ERK. In NIH 3T3 cells transfected with H-rasG12V, Kobe0065 inhibited the colony formation with IC50 value of 0.5 μM. Kobe0065 also showed effect on other cancer cells carrying activated ras oncogenes, such as PANC-1(K-rasG12V), HT1080 (N-rasQ61L) and HCT116 (H-rasG13D). Moreover, in mice bearing SW480 xenografts, administration of Kobe0065 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg. This effect turned to be more distinct when the dose was up to 160 mg/kg [1].

D(+)-樟脑（天然） 98%  4-溴吲哚 98%

桉叶油醇 99%  N,N-二甲基丙烯基脲 99%

锂 低钠级，99.95% metals basis  5-羟基吲哚 98.0%

金属锂 电池级，99.9% metals basis  (RS)-1H-吲哚-2-羧酸 97%

锂 高钠级，98.5%  二氢吲哚 99%

蒎烷 99%  吲哚 CP，>98.5% (GC)

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PHA-84812510mM (in 1mL DMSO)5mg 10mg>98.00%Cas No. 802539-81-7C25H32N8O

PHA-76749110mM (in 1mL DMSO)10mg 50mg>98.00%Cas No. 845714-00-3C12H11N3O

PD 4078241mg 5mg 10mg>98.00%Cas No. 622864-54-4C20H12N2O3

Picolinamide10mM (in 1mL DMSO)100mg 500mg>98.00%Cas No. 1452-77-3C6H6N2O

Puromycin dihydrochloride10mM (in 1mL DMSO)20mg 50mg>98.00%Cas No. 58-58-2C22H29N7O5.2HCl