性能参数

产品名称

Geraniin

规格

20mg

货号

GOY-Y2382

 含量

>98.00%

CAS

Cas No. 60976-49-0

别名

化学名

分子式

C41H28O27

分子量

分子量 952.08

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml

储存条件

4°C, away from moisture and light

General tips

用途

仅供科研

价格

电询

详细内容

Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC50 of 43 μM.

The IC50 value of TNF-α release inhibition is 43 μM for Geraniin[1]. Geraniin has long been used as a medicinal herb and possesses numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities. Geraniin significantly decreases the viability of OVCAR3 and SKOV3 cells in a concentration-dependent fashion. The IC50 value for Geraniin treatment is 34.5±2.8 μM in OVCAR3 cells and 23.6±1.9 μM in SKOV3 cells. However, Geraniin up to the maximal concentration used (80 μM) has no significant impact on the viability of normal human ovarian surface epithelial cells. Treatment with 10 and 40 μM of Geraniin for 48 h causes a significant increase in apoptosis (16.8±1.2% and 22.6±1.4%, respectively), compared with control OVCAR3 cells (3.9±1.1%). Similar results are observed in SKOV3 cells[2].

Treatment with Geraniin prior to application of okadaic acid delays development of tumors compared with control group, reduces the percentage of tumor bearing mice from 80.0% to 40.0%, and reduces the average numbers of tumor per mouse from 3.8 to 1.1 in week 20. It is also showed that oral administration of Geraniin to rats (50 mg/kg/d or 100 mg/kg/d) inhibit the elevation of serum total cholesterol, lipid peroxide, free fatty acid, triglyceride, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase induced by treatment with peroxidized oil[1].

溴丙烷 CP  四氯化钛 99.99% metals basis

溴丙烷 >99.0%(GC)  冰乙酸 CP,99.0%

3,4,5-**氧基苯甲醛 98%  丙烯酸丁酯 AR,99%

磷酸三乙酯 CP,98%  丙烯酸异辛酯 分析标准品,≥99.5% (GC)

磷酸三乙酯 GR,99.5%  丙烯酸甲酯 CP,98%

芹菜素 分析标准品，≥98%  乙酸乙烯酯 Standard for GC, ≥99.5% (GC)

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Cdc7-IN-510mM*1 mL in DMSO 5 mg 10 mg 25 mg 50 mg 100 mg>95.00%Cas No. 1402057-86-6C25H23N3O5

Purity: >

Althiomycin1 mg>90.00%Cas No. 12656-40-5C16H17N5O6S2

3'-Dephosphocoenzyme A1mg 5mg 10mg>90.00%Cas No. 3633-59-8C21H35N7O13P2S

8-Hydroxyguanine (hydrochloride)10mg 25mg 50mg 100mg>90.00%Cas No. 1246818-54-1C5H5N5O2?HCl