性能参数

产品名称

Formononetin

规格

20mg

货号

GOY-Y2378

 含量

>98.00%

CAS

Cas No. 485-72-3

别名

化学名

7-hydroxy-3-(4-methoxyphenyl)chromen-4-one

分子式

C16H12O4

分子量

分子量 268.27

溶解度

DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 25 mg/ml

储存条件

General tips

用途

仅供科研

价格

电询

详细内容

Formononetin (Formononetol; Flavosil) is a bioactive component extracted from the red clover; inhibits the proliferation of DU-145/PC-3 cells in a dose-dependent manner.IC50 value:Target: anti-cancer in vitro: formononetin inhibited the proliferation of DU-145 cells in a dose-dependent manner. DU-145 cells treated with different concentrations of formononetin displayed obvious morphological changes of apoptosis under fluorescence microscopy. In addition, formononetin increased the proportion of early apoptotic DU-145 cells, down-regulated the protein levels of Bcl-2 and up-regulated those of RASD1 and Bax [1]. Formononetin significantly inhibited the cell growth of PC-3 in a dose-dependent manner, but no such effect was observed in RWPE1 cells. Formononetin treatment contributed to the reduced Bcl-2 protein level and the elevated Bax expression in PC-3 cells, thereby resulting in the increasing Bax/Bcl-2 ratios. Furthermore, the phosphorylated level of p38 in PC-3 cells was activated through the FN treatment, whereas the endogenous Akt phosphorylation was blocked [2]. Compared with the control, formononetin inhibited the proliferation of MCF-7 cells and effectively induced cell cycle arrest. The levels of p-IGF-1 R, p-Akt, cyclin D1 protein expression, and cyclin D1 mRNA expression were also downregulated [3].in vivo: formononetin also prevented the tumor growth of human breast cancer cells in nude mouse xenografts [3].

脂肪酶 10万U/g  D（-）-酒石酸 GR,99.5%

胰脂肪酶 牛胰腺，powder, 15-35 units/mg  甲基丙烯酸丁酯 GR,99%

木瓜蛋白酶 ≥3 units/mg  甲基丙烯酸丁酯(单体) CP，97%

胰蛋白酶（牛胰脏） potency ≥2500 units/mg  甲基丙烯酸丁酯 Standard for GC,>99.5%(GC)

硝酸铈铵 AR,99.0%  对甲氧基苯胺 AR，99.0%

氧化铈 99.9% metals basis，黄色  烟碱 95%（剧毒品）

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Purity: >95.00%

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