性能参数

产品名称

Cereblon modulator 1

规格

5mg 10mg 25mg 50mg 100mg

货号

GOY-Y2319

 含量

>99.00%

CAS

1860875-51-9

别名

N/A

化学名

N/A

分子式

C22H18ClF2N3O4

分子量

分子 461.85

溶解度

DMSO: 250 mg/mL (541.30 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

A different CRBN-binding compound, Cereblon modulator 1 (compound F), that demonstrates anti-proliferative activity in non-AML hematological cancer cell lines (such as multiple myeloma) does not inhibit cell growth in any of the 11 AML cell lines tested, including the ten cell lines that are sensitive to the growth inhibitory activity of Compound D. However, when excess Cereblon modulator 1 is added to KG-1 AML cell cultures in the presence of Compound D, the anti-proliferative activity of Compound D is reduced, presumably due to competition for binding of Compound D to CRBN. The relative impact of Cereblon modulator 1 on the anti-proliferative effect of Compound D progressively increased with increasing concentrations of Cereblon modulator 1. In the presence of 100 μμ Cereblon modulator 1, the potency of Compound D in inhibiting cell growth reduced by approximately 60-fold, and the potency of Compound D in inducing apoptosis reduced by approximately 40-fold[1].

[1]. Ellen Filvaroff, et al. Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies. WO2017120446A1. [2]. CC-90009

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