性能参数

产品名称

Durvalumab

规格

1mg 5mg

货号

GOY-Y2300

 含量

>99.00%

CAS

1428935-60-7

别名

N/A

化学名

N/A

分子式

N/A

分子量

分子 N/A

溶解度

Soluble in DMSO

储存条件

Store at 2-8°C

General tips

用途

仅供科研

价格

电询

详细内容

Durvalumab (MEDI 4736) is an humanized anti-PD-L1 monoclonal antibody[1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively[2]. IC50: 0.1 nM (PD-L1/PD-1), 0.04 nM (PD-L1/CD80)[2]

Durvalumab inhibits tumor growth in mouse xenograft models of human melanoma (A375) and pancreatic (HPAC) tumour cell lines, via a T-cell-mediated mechanism. Durvalumab (5-0.01 mg/kg for NOD/SCID mice with HPAC tumor; 5-0.1 mg/kg for NOD/SCID mice with A375 tumor; administration i.p.; twice per week; for 3 weeks) significantly inhibits the tumor growth of both HPAC and A375 xenografts compared with an isotype-matched control antibody. Tumor growth inhibition of the HPAC cells reaches 74%, whereas inhibition of the A375 cells reaches 77%. When administered in the absence of T cells, Durvalumab has no effect on the growth of the A375 tumor xenograft[2]. Animal Model: NOD/SCID mice with HPAC tumor, following coimplantation of primary human T cells; NOD/SCID mice with A375 tumor, following coimplantation of primary human T cells[2]

[1]. Faiena I, et al. Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma. Drug Des Devel Ther. 2018 Jan 23;12:209-215. [2]. Stewart R, et al. Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody. Cancer Immunol Res. 2015 Sep;3(9):1052-62.

胆盐硫乳琼脂培养基（药典） BR  L-组氨酸盐酸盐，一水 99%

葡萄糖肉汤 BR  非动物源，EP, JP, USP ；用于细胞培养，98.5 to 101.0%

氨基酸脱羧酶试验培养基基础 BR  L-组氨酸盐酸盐，一水 Ultra pure,≥99.5% (AT)

曙红亚甲基蓝琼脂培养基 BR  L-异亮氨酸 99%

品红亚硫酸钠培养基 BR  L-亮氨酸 99%

肠道菌增菌肉汤 BR  L-赖氨酸盐酸盐 99%

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