性能参数

产品名称

CDDO-EA

规格

10mM*1mL in DMSO 2mg 5mg 10mg 50mg 100mg

货号

GOY-Y2292

 含量

>98.00%

CAS

932730-51-3

别名

N/A

化学名

N/A

分子式

C33H46N2O3

分子量

分子 518.73

溶解度

DMSO: ≥ 34 mg/mL (65.54 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS[1]. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS[2].

The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%)[1].

[1]. Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96. [2]. Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.

琼脂 BR  蒿甲醚 98%

α-淀粉酶 BR  青蒿琥酯 98%

耐高温α-淀粉酶 BR  青蒿素 98%

酵母浸出粉胨葡萄糖琼脂培养基 BR  辅酶Q10 98%

碱性琼脂 BR  去氢表雄酮 99%

号琼脂 BR  多烯紫杉醇 98%

LY28016535mg 10mg 50mg 100mg>98.00%Cas No. 1206799-15-6C30H22F2N6O3

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LM 22A45mg 10mg 25mg 50mg>98.00%Cas No. 37988-18-4C15H21N3O6

Linsitinib10mM (in 1mL DMSO) 5mg 10mg 50mg>98.00%Cas No. 867160-71-2C26H23N5O

Motesanib10mg 25mg 50mg 100mg>98.00%Cas No. 453562-69-1C22H23N5O

MLR 10235mg 10mg 25mg 50mg>98.00%Cas No. 41964-07-2C11H10N2O2

MLi-22mg 5mg 10mg 50mg>98.00%Cas No. 1627091-47-7C21H25N5O2