性能参数

产品名称

CUDC-427

规格

10mM*1mLinDMSO 2mg 5mg 10mg 50mg

货号

GOY-Y2281

 含量

>98.00%

CAS

1446182-94-0

别名

N/A

化学名

N/A

分子式

C29H36N6O4S

分子量

分子 564.7

溶解度

DMSO : ≥ 61 mg/mL (108.02 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

GDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 μM (56.5 ng/mL)[1].

GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species[1].

[1]. Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13.

1,2,4-苯三酚 97%  甘油 ≥99%, FCC

4-氯苯胺盐酸盐 98%  甘油 for HPLC, ≥99.5%

2,4-二氯氟苯  99%  甘油 for electrophoresis, ≥99%

3,4-二甲氧基苯甲醛 99%  甘油 EP, BP, JP, USP级

对苯二胺盐酸盐 AR,98.5%    甘油 分析标准品

间硝基苯甲醛 98%  薄层层析硅胶 G60

PD 90780 (hydrate)1mg 5mg 10mg>98.00%Cas No. N/AC19H14N4O4 ? XH2O

PD 1809701mg 5mg 10mg>98.00%Cas No. 287204-45-9C21H15Cl2FN4O

PF-04217903 methanesulfonate5mg 25mg 100mg>98.00%Cas No. 956906-93-7C20H20N8O4S

PF-62744841mg 5mg 10mg>98.00%Cas No. 1035638-91-5C18H14ClFN4O2

PF-562271 HCl5mg 10mg 50mg>98.00%Cas No. 939791-41-0C21H21ClF3N7O3S

PF-0644747510mM (in 1mL DMSO) 5mg 10mg>98.00%Cas No. 1527473-33-1C17H15N5O

PROTAC FAK degrader 1100mg 250mg 500mg>98.00%Cas No. 2301916-69-6C47H56F3N9O8S2