性能参数

产品名称

CCI-007

规格

5 mg 10 mg 25 mg 50 mg 100 mg

货号

GOY-Y2276

 含量

>98.00%

CAS

939228-52-1

别名

N/A

化学名

N/A

分子式

C15H16N2O5S

分子量

分子 336.36

溶解度

DMSO: 25 mg/mL (74.33 mM; ultrasonic and warming and heat to 80°C)

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia[1].Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal[1].Resistance to CCI-007 can occur by upregulation of MLL target gene expression[1].CCI-007 reverts the aberrant elevated transcription of disease-driving factors HOXA9, MEIS1, and CMYC downstream of the pathogenic MLL fusion protein, thereby inducing MLL-r leukemia cell death[2]. Cell Viability Assay[1] Cell Line: PER-485, MOLM-13, MV4;11 cells.

[1]. Klaartje Somers, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. 2016 Jul 19;7(29):46067-46087. [2]. Klaartje Somers, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 May;38(20):3824-3842.

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