性能参数

产品名称

Dasatinib hydrochloride

规格

50mg 100mg 200mg 500mg

货号

GOY-Y2266

 含量

>98.00%

CAS

854001-07-3

别名

N/A

化学名

N/A

分子式

C22H27Cl2N7O2S

分子量

分子 524.47

溶解度

DMSO: 15 mg/mL (28.60 mM and warming); H2O: 10 mg/mL (19.07 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Dasatinib potently inhibits wild-type Abl kinase and all mutants except T315I over a narrow range (IC50≤1.7 nM). Dasatinib (IC50: 0.8 nM) displays 325-fold greater potency compared with Imatinib against cells expressing wild-type Bcr-Abl in Ba/F3 cells[1].

Daily treatment with Dasatinib (50 mg/kg) is initiated on day 10. Using this approach, a significant inhibition of BCPAP orthotopic tumor growth is observed 6 days after treatment (day 16, P=0.014), which is sustained through days 23 and 29 (P=0.0003), compared with vehicle-treated mice[3]. Metabolism studies of Dasatinib (50 mg/kg) in rat suggested that Dasatinib is the major circulating component, whereas multiple metabolites contributed to the remaining 40-60% of the sample radioactivity at 4 h post dose[4].

[1]. O'Hare T, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res. 2005 Jun 1;65(11):4500-5. [2]. Shah NP, et al. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood. 2006 Jul 1;108(1):286-91. [3]. Chan CM, et al. Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis. Clin Cancer Res. 2012 Jul 1;18(13):3580-91. [4]. Shen Z, et al. Metabolite profiling of dasatinib dosed to Wistar Han rats using automated dried blood spot collection. J Pharm Biomed Anal. 2012 Aug-Sep;67-68:92-7.

乙烯(2-氯乙基)醚 98%  柱层层析硅胶 60目以上 280um

1-乙烯基咪唑 99%  柱层层析硅胶 40-80目 180-450um

邻香兰素 99%  柱层层析硅胶 80-100目 150-180um

伍德沃德氏试剂K 98%  柱层层析硅胶 80-120目 120-180um

对二甲酚蓝 ≥95%(HPLC)  柱层层析硅胶 100-160目 97-150um

1,4-苯二甲胺 99%  柱层层析硅胶 100-200目 75-150um

GSK 14310 mg 50 mg>98.00%Cas No. N/AC17H22N6O2.2HCl

GNE-6468250mg 500mg>98.00%Cas No. 1677668-27-7C23H16ClN3O4

GNE-4997250mg 500mg>98.00%Cas No. 1705602-02-3C25H27F2N5O3S

GNE-0946250mg 500mg>98.00%Cas No. 1677667-24-1C22H12ClF3N2O4

Harmine (Telepathine)10mM*1mLinDMSO 500mg>98.00%Cas No. 442-51-3C13H12N2O

HA-100 (hydrochloride)5mg 10mg>98.00%Cas No. 210297-47-5C13H15N3O2S ? 2HCl

GZD856250mg 500mg>98.00%Cas No. 1257628-64-0C29H27F3N6O