性能参数

产品名称

CRT5

规格

1mg 5mg 10mg 25mg

货号

GOY-Y2261

 含量

>98.00%

CAS

1034297-58-9

别名

CRT0066051

化学名

3-[6-amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]-benzamide

分子式

C28H30N4O2

分子量

分子 454.6

溶解度

≤2.5mg/ml in DMSO;0.25mg/ml in dimethyl formamide

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

In vitro: The non-linear regression analysis revealed that LD50 value of CRT5 was 17 μM. The biochemical IC50 value of CRT5 for PKD1, PKD2 and PKD3 were 1, 2 and 1.5 nM, respectively [1]. CRT5 (1 μM) completely inhibited PKD1 and PKD2, but showed little inhibitory effect on the PKC isoforms. CRT5 significantly reduced VEGF-induced phosphorylation of HSP27 at the position Ser82. CRT5 significantly reduced the migratory response towards VEGF by 42–51%. CRT5 decreased the proliferation of control cells not treated with VEGF to a less extent. VEGF increased HUVEC tubule formation in a collagen-based assay. CRT5 markedly inhibited VEGF-induced tubulogenesis [1].

Reference:

[1] Evans I M, Bagherzadeh A, Charles M, et al.  Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells[J]. Biochemical Journal, 2010, 429(3): 565-572.

1,3,5-**苯标准溶液 1mg/ml，基质：甲醇,用于水分析  葡聚糖40 分子量40000

四丁基硫酸氢铵 离子对色谱专用  葡聚糖5 分子量5000

偏苯**酸 99%  葡聚糖20 分子量20000

六氟磷酸四丁胺 98%  三氯蔗糖  98%

四丁基磷酸二氢铵 0.5mol/L 水溶液，离子对色谱级  阿仑膦酸钠 97%

四硫富瓦烯 98%  氨力农 98%

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CAY1078110 mg 50 mg 100 mg 250 mg>90.00%Cas No. 1210360-87-4C11H9N3O3

Purity: >98.00%Purity:分子式

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