Bax inhibitor peptide P5
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产品名称:
Bax inhibitor peptide P5
产品型号:
GOY-Y2170
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-26
简单介绍
Bax inhibitor peptide P5≥ 61.7mg/mL in DMSO, ≥ 101 mg/mL in EtOH with ultrasonic, ≥ 94.4 mg/mL in H2O
Bax inhibitor peptide P5
的详细介绍
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性能参数
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产品名称
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Bax inhibitor peptide P5
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规格
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5mg 10mg 100mg
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货号
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GOY-Y2170
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含量
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>98.00%
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CAS
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579492-83-4
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别名
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化学名
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(2S)-2-[[(2S)-6-amino-2-[[(2S)-4-methyl-2-[[(2S)-4-methylsulfanyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]pentanoyl]amino]hexanoyl]amino]pentanedioic acid
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分子式
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C27H48N6O8S
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分子量
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分子 616.77
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溶解度
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≥ 61.7mg/mL in DMSO, ≥ 101 mg/mL in EtOH with ultrasonic, ≥ 94.4 mg/mL in H2O
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储存条件
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Desiccate at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Bax is a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. Bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].
BIP P5 is a membrane-permeable peptide inhibitor of Bax translocation to mitochondria. In HeLa cells, BIP P5 protected cells from UVC- and STS-induced apoptosis. In U87-MG glioma cells, MCF-7 breast cancer cells and LNCaP prostate cancer cells, BIP P5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. While BIP P5 did not suppress UVC- or STS-induced apoptosis in Bax-deficient cells (DU145), which suggested BIP P5 only suppressed Bax-mediated apoptosis. The caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by BIP P5. BIP P5 inhibited the interaction of Ku70 and endogenous Bax in a dose-dependent way [1].
Reference:
[1]. Sawada M, Hayes P, Matsuyama S. Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat Cell Biol, 2003, 5(4): 352-357.
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