性能参数

产品名称

BAY 61-3606 (hydrochloride)

规格

1mg 5mg 10mg

货号

GOY-Y2168

 含量

>98.00%

CAS

1615197-10-8

别名

N/A

化学名

N/A

分子式

C20H18N6O3?HCl

分子量

分子 426.9

溶解度

DMF: 1 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:30): 0.03 mg/mL,Ethanol: 0.1 mg/mL

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM; IC50 = 10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. At 3 mg/kg, oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma.

柱层层析硅胶 100-180目 88-150um  甜菊苷 80%

柱层层析硅胶 100-200目 75-150um  1-Boc-哌嗪 98%

柱层层析硅胶 160-200目 75-98um  3-环己烯-1-甲酸 98%

柱层层析硅胶 200-300目 54-75um  1,2-环己烷二甲酸二缩水甘油酯 90%

柱层层析硅胶 230-400目 38-54um  三缩水甘油基对氨基苯酚 90%

柱层层析硅胶 300-400目 37-54um  9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物 97%

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