性能参数

产品名称

CMLD-2

规格

5 mg 10 mg

货号

GOY-Y2154

 含量

>98.00%

CAS

958843-91-9

别名

N/A

化学名

N/A

分子式

C31H31NO6

分子量

分子 513.58

溶解度

DMSO: 50 mg/mL (97.36 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

CMLD-2 (1-75 μM; 24-72 h) inhibits thyroid cancer cell viability[2].CMLD-2 (20-30 μM; 24-48 h) activates caspases and induces apoptotic cell death in H1299 and A549 cells[3].CMLD-2 (30 μM; 24-48 h) induces G1 cell cycle arrest and mitochondrial perturbation in H1299 and A549 cell[3].CMLD-2 (30 μM; 24-48 h) reduces expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells[3].CMLD-2 (35 μM; 72 h) decreases directional migration capability in SW1736, 8505C, BCPAP and K1 cells. CMLD-2 induces a strong decrease of MAD2 mRNA levels in SW1736, 8505C, BCPAP and K1 cells[2]. Cell Viability Assay[2] Cell Line: SW1736, 8505C, BCPAP and K1 cells

[1]. Wu X, et, al. Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol. 2015 Jun 19;10(6):1476-84. [2]. Allegri , et, al. The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells. Sci Rep. 2019 May 14;9(1):7374. [3]. Muralidharan R, et, al. HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells. Sci Rep. 2017 Aug 30;7(1):9694.

甲基丙烯酸甲酯(MMA) Standard for GC, ≥99.5% (GC)  4-氯苯氧乙酸 98%

甲基丙烯酸甲酯  >99.5%(GC)  对氯苯酚 Standard for GC

磷酸氢镁,三水 AR  对氯苯酚 AR，99%

对二氯苯 Standard for GC，>99.5%(GC)  对氯苯酚 CP，98%

对二氯苯 CP,97.0%  对氯苯酚 分析标准品，>99.5%(GC）

对二氯苯 分析标准品，>99.8%(GC)  对氯苯酚标准溶液 1000μg/ml，溶剂：甲醇

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