性能参数

产品名称

Dienogest

规格

10mM (in 1mL DMSO) 10mg 25mg 50mg 100mg

货号

GOY-Y2099

 含量

>98.00%

CAS

65928-58-7

别名

化学名

2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile

分子式

C20H25NO2

分子量

分子 311.42

溶解度

≥ 14.8mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. Target: progesterone receptor agonistDienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms. It is a non-ethinylated progestin which is structurally related to testosterone [1]. Complete sperm suppression was observed in rats sacrificed either 60 or 90 days after dienogest (DNG)+ testosterone undecanoate (TU) administration, for two injections at 45-day interval. The neutral α-glucosidase activity in these treated rats remained in the normal range. Germ cell loss due to apoptosis was frequently observed both after 60 or 90 days of combination treatment. Significant decline in serum gonadotropin and testosterone, both serum and intratesticular levels, were observed in the treated rats. Following stoppage of treatment (given at 45-day interval) after two (0 and 45 days) or three injections (0, 45 and 90 days), complete restoration of spermatogenesis was observed by 120 and 165 days, respectively [2].Clinical indications: Adenomyosis; EndometriosisFDA Approved Date: 1995 Toxicity: weight gain; increased blood pressure; breast tenderness and nausea

References:

[1]. Oettel M, et al. Effect of ethinyl estradiol-dienogest combination on serum androgen concentrations. Zentralbl Gynakol. 1997;119(12):597-606.

[2]. Meena R, et al. Extended intervention time and evaluation of sperm suppression by dienogest plus testosterone undecanoate in male rat. Contraception. 2012 Jan;85(1):113-21.

2-氰-3-甲基吡啶 98%  N,N-二甲基乙胺 99%

2-氯甲基-3,5二甲基-4-甲氧基吡啶盐酸盐  98%  异佛尔酮二胺 99%

环丙胺 98%  乙酰乙酸基甲基丙烯酸乙酯 95%

环丙基甲基酮 98%  2,2-双(羟甲基)丙酸 98%

4-氯-4'-氟苯丁酮 97%  1，4-丁二醇 AR,98%

6-氯-2-己酮 98%  1,3-丁二醇 99%

Ungeremine1 mg 5 mg 10 mg 25 mg>98.00%Cas No. 12/2/2121C16H12NO3

Vinclozolin M25 mg 10 mg 25 mg 50 mg>98.00%Cas No. 83792-61-4C11H11Cl2NO2

Vidofludimus5mg 10mg 50mg 100mg>98.00%Cas No. 717824-30-1C20H18FNO4

Veledimex S enantiomer (INXN-1001 S enantiome)10mM*1mLinDMSO 1mg 5mg 10mg>98.00%Cas No. 1093131-03-3C27H38N2O3

β-Nicotyrine1mg 5mg 10mg 25mg>98.00%Cas No. 487-19-4C10H10N2

Zaprinast10mg 50mg 100mg 250mg>98.00%Cas No. 37762-06-4C13H13N5O2

Win-620051mg 5mg 10mg 20mg>98.00%Cas No. 152633-54-0C12H10N4O