性能参数

产品名称

Epothilone B (EPO906, Patupilone)

规格

10mM (in 1mL DMSO) 5mg 25mg 100mg

货号

GOY-Y2087

 含量

>98.00%

CAS

152044-54-7

别名

化学名

(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

分子式

C27H41NO6S

分子量

分子 507.68

溶解度

≥ 25.4mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Epothilone B (EPO906, Patupilone) is a naturally occurring microtubule-stabilizing macrolide that was first isolated from the myxobacterium Sorangium cellulosum. The EC0.01 value of Epothilone B is 1.8 nM [1].

Epothilone B exhibits the same mechanism of action as paclitaxel. More importantly, in cell culture, Epothilone B is active against paclitaxel-resistant cell lines that express P-glycoprotein. Furthermore, Epothilone B has better solubility in water than paclitaxel [1].

Epothilone B induced an increase in the level of the intracellular free calcium only during the longer times following the treatment in SKOV-3 cells. Besides, the ovarian cancer cells treated with Epothilone B showed a time course dependent increase in the cytosolic fraction of cytochrome c [2].

References:

[1] Regueiro-Ren A1, Borzilleri RM, Zheng X, Kim SH, Johnson JA, Fairchild CR, Lee FY, Long BH, Vite GD. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6.

[2] Rogalska A1, Gajek A2, Marczak A2. Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells. Toxicol In Vitro. 2014 Jun;28(4):675-83.

异丙醇 for LC-MS, ≥99.9% (GC)  乙酰丙酮氧钒 95%

异丙醇 ACS 光谱级, ≥99.5%  羟基脲 98%

异丙醇 Plus, for HPLC, 99.9%  尿嘧啶 99%

异丙醇 制备色谱级, 99.8%  尿嘧啶 99.5%,用于细胞培养

异丁醇 >99.0%(GC)  胆固醇 AR,>95.0%(GC)

正辛醇 Standard for GC,>99.5%  胆固醇 >97.0%(GC)

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N-(p-amylcinnamoyl) Anthranilic Acid10mM (in 1mL DMSO) 25mg 50mg 100mg>98.00%Cas No. 110683-10-8C21H23NO3

N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)1 g 5 g 10 g 25 g>98.00%Cas No. N/AC12H14N2O5·XH2O

N-(3-Phenylpropionyl)glycine50 mg 100 mg 250 mg 500 mg>98.00%Cas No. 56613-60-6C11H13NO3

N-Nornuciferine5mg 10mg 50mg 100mg>98.00%Cas No. 4846-19-9C18H19NO2

N-Despropyl Ropinirole5 mg 10 mg 25 mg 50 mg>98.00%Cas No. 106916-16-9C13H18N2O

N-Desmethyl Sildenafil1mg 5mg 10mg 50mg>98.00%Cas No. 139755-82-1C21H28N6O4S