性能参数

产品名称

Euscaphic acid

规格

1mg 5mg

货号

GOY-Y2049

 含量

>98.00%

CAS

53155-25-2

别名

N/A

化学名

N/A

分子式

C30H48O5

分子量

分子 488.7

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].

Euscaphic acid induces apoptosis and cell cycle arrest in NPC cells by suppression of the PI3K/AKT/mTOR signaling pathway[2].

[1]. Murakami C, et al. Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochim Biophys Acta. 2002 Apr 29;1596(2):193-200. [2]. Dai W, et al. Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway. Am J Transl Res. 2019 Apr 15;11(4):2090-2098.

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