性能参数

产品名称

BAM7

规格

10mg 50mg

货号

GOY-Y2018

 含量

>98.00%

CAS

331244-89-4

别名

BAM 7;BAM-7

化学名

(4E)-4-[(2-ethoxyphenyl)hydrazinylidene]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)pyrazol-3-one

分子式

C21H19N5O2S

分子量

分子 405.47

溶解度

DMF: 5 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.33 mg/ml,DMSO: 2 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

In the competitive fluorescence polarization assay (FPA), BAM7 competes with FITC–BIM SAHB for BAX binding site(BH3) in a dose dependent manner. BAM7 shows no antiapoptotic or BAKΔC competitive binding interactions even at 50 μM dosing, revealing a remarkable selectivity of BAM7 for BAX. The interaction between BAM7 and BAX at the very surface induces the characteristic structural changes that yield functional BAX oligomerization. In the in vitro assay, BAM7 induces BAX-dependent cell death but not the cells with BAK. BAM7 could be developed to a new generation of apoptotic modulators that directly activate BCL-2 family executioner proteins in cancer

and other diseases driven by pathologic apoptotic blockades [1].

References:

[1] Evripidis Gavathiotis, Denis E Reyna, Joseph A Bellairs, Elizaveta S Leshchiner, and Loren D Walensky. Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 July ; 8(7): 639–645.

十四烷基**基溴化铵 99%  硫酸安普霉素 95%

甲胺盐酸盐 CP，97.0%  伊维茵素 97%

四丁基溴化铵 AR,99.0%  甲烷磺酸 99%

三乙胺盐酸盐 99%  苯乙酮  GR,≥99.0% (GC)

四甲基氯化铵 AR  乙酸酐 AR,98.5%（易制毒品）

四丙基溴化铵 98%  乙酸酐 CP,96.0%（易制毒品）

α-Cyclodextrin (hydrate)10 g 25 g 50 g 100 g>95.00%Cas No. 51211-51-9C36H60O30.XH2O

(±)13(14)-EpDPA25μg 50μg 100μg 500μg>95.00%Cas No. 895127-64-7C22H32O3

(±)11(12)-EET25μg 50μg 100μg 500μg>95.00%Cas No. 123931-40-8C20H32O3

(±)10(11)-EpDPA25μg 50μg 100μg 500μg>95.00%Cas No. 895127-65-8C22H32O3

(±)5(6)-EET25μg 50μg 100μg 500μg>95.00%Cas No. 87173-80-6C20H32O3

(±)4(5)-DiHDPA lactone25μg 50μg 100μg 250μg>95.00%Cas No. 845673-68-9C22H32O3

(±)16(17)-DiHDPA50μg 100μg 500μg 1mg>95.00%Cas No. 1345275-27-5C22H34O4