性能参数

产品名称

AZT triphosphate

规格

1mg

货号

GOY-Y1989

 含量

>98.00%

CAS

92586-35-1

别名

N/A

化学名

N/A

分子式

C10H16N5O13P3

分子量

分子 507.18

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway[1][2][3].

Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1].

[1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.

咖啡酸 99%  BOC-D-2-氯苯丙氨酸 98%

咖啡酸 分析标准品  4-溴-2-甲氧基苯酚 98%

4-香豆酸 98%  N-BOC-L-苯丙氨醛 97%

4-香豆酸 分析标准品，≥99%  Boc-L-炔丙基甘氨酸 98%

卡铂 98%  三氟甲烷磺酸铋 99%

顺铂 Pt, 65%  N-Boc-D-苯丙氨醇 98%

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