性能参数

产品名称

AZT triphosphate TEA

规格

1mg

货号

GOY-Y1988

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C10H16N5O13P3.xC6H15N

分子量

分子 N/A

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3].

Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1].

[1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.

硝酸铋(III) 五水合物 AR ,99.0%  BOC-D-2-甲基苯丙氨酸 98%

硝酸铋(III) 五水合物 ACS,≥98.0%  BOC-D-4-溴苯丙氨酸 98%

硝酸铋 CP,99.0%  BOC-L-2-溴苯丙氨酸 98%

硝酸铋(III) 五水合物 ≥99.99% metals basis  BOC-L-3,4-二氯苯丙氨酸 98%

硝酸铋(III) 五水合物 ≥99.995% metals basis  BOC-D-3,4-二氯苯丙氨酸 98%

咖啡酸 98%  BOC-L-2-氯苯丙?

4-Nitrophenyl-N-acetyl-α-D-galactosaminide1mg 5mg 10mg 25mg>98.00%Cas No. 23646-68-6C14H18N2O8

4-Methylumbelliferyl-β-D-N,N',N''-Triacetylchitotrioside500μg 1mg 5mg 10mg>98.00%Cas No. 53643-13-3C34H47N3O18

4-Methylumbelliferyl-β-D-Galactoside0 1 2 3 4 5 6 7 8 9 10 500 mg 1 g 5 g>98.00%Cas No. 6160-78-7C16H18O8

4-Methylumbelliferyl-α-D-Galactopyranoside10mg 25mg 50mg 100mg>98.00%Cas No. 38597-12-5C16H18O8

6,7-Dimethyltetrahydropterin (hydrochloride)10mg 50mg 100mg 500mg>98.00%Cas No. 167423-51-0C8H13N5O ? HCl

6',7'-Epoxybergamottin1mg 5mg 10mg 25mg>98.00%Cas No. 206978-14-5C21H22O5

7-Ethoxycoumarin100 mg 250 mg 500 mg 1 g>98.00%Cas No. 31005-02-4C11H10O3