性能参数

产品名称

(±)-trans-GK563

规格

mg 5mg 10mg

货号

GOY-Y1984

 含量

>94.00%

CAS

2351820-19-2

别名

N/A

化学名

N/A

分子式

C16H22O2

分子量

分子 246.3

溶解度

Chloroform: slightly soluble,DMSO: slightly soluble,Methanol: slightly soluble

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).1 It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells.

|1. Dedaki, C., Kokotou, M.G., Mouchlis, V.D., et al. β-Lactones: A novel class of Ca2+-independent phospholipase A2 (group VIA iPLA2) inhibitors with the ability to inhibit β-cell apoptosis. J. Med. Chem. 62(6), 2916-2927 (2019).

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硫酸钴，七水 AR，99.5%  异喹啉 97%

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