性能参数

产品名称

Amifostine thiol

规格

10 mg

货号

GOY-Y1981

 含量

>90.00%

CAS

31098-42-7

别名

N/A

化学名

N/A

分子式

C5H14N2S

分子量

分子 134.24

溶解度

H2O: 250 mg/mL (1862.34 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)

储存条件

4°C, protect from light, stored under nitrogen

General tips

用途

仅供科研

价格

电询

详细内容

Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine . Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].

Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures[1].Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation[1].Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation[1].Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability[1].Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment[1].Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage[1].Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81[2].Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells[3].

[1]. Jaroslaw Dziegielewski, et al. WR-1065, the Active Metabolite of Amifostine, Mitigates Radiation-Induced Delayed Genomic Instability. Free Radic Biol Med. 2008 Dec 15; 45(12): 1674-1681. [2]. Olivier Pluquet, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87. J Biol Chem. 2003 Apr 4;278(14):11879-87. [3]. J. S. Murley, et al. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun; 30(6): 283-294.

丙二醇甲醚醋酸酯 99%  香豆素 分析标准品，≥99.7%

聚乙二醇二甲醚 average Mn ~250  2-乙?；?3-甲基吡嗪  98%

乙二醇丙醚  99.4%  丙酸钠 分析标准品

三乙二醇二甲醚 99%  丙酸钠 99%

四乙二醇二甲醚 99%  丙酸钠 用于昆虫细胞培养, ≥99.0%

四乙二醇二甲醚 standard for GC ,≥99.5% (GC)   对苯醌 97%

(±)14(15)-EpEDE25μg 50μg 100μg 500μg>98.00%Cas No. 351533-80-7C20H34O3

(±)14(15)-EET25μg 50μg 100μg 500μg>98.00%Cas No. 197508-62-6C20H32O3

(±)12(13)-DiHOME25μg 50μg 100μg 500μg>98.00%Cas No. 263399-35-5C18H34O4

(±)11(12)-EpETE25μg 50μg 100μg 500μg>98.00%Cas No. 504435-15-8C20H30O3

(±)5(6)-DiHET lactone25μg 50μg 100μg 250μg>98.00%Cas No. 213126-92-2C20H32O3

(±)4(5)-EpDPA methyl ester25μg 50μg 100μg 500μg>98.00%Cas No. 121818-29-9C23H34O3

(±)19(20)-EpDPA25μg 50μg 100μg 500μg>98.00%Cas No. N/AC22H32O3