性能参数

产品名称

(S)-3'-hydroxy Blebbistatin

规格

1mg 5mg 10mg

货号

GOY-Y1961

 含量

>95.00%

CAS

2097136-42-8

别名

N/A

化学名

N/A

分子式

C18H16N2O3

分子量

分子 308.3

溶解度

DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 12.5 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a 3'-hydroxy group decreases the inherent fluorescence while retaining the activity of (-)-blebbistatin. (S)-3'-hydroxy-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.

盐酸  电子级,37%  二氯乙腈 98%

氢氟酸 HPLC  二氯乙腈 Standard for GC, ≥99.5% (GC)

氢氟酸 ACS  二氯乙腈 分析标准品

氢氟酸 电子级，49wt. % in H2O，≥99.99998%metals basis  3,3-二甲基丁酰氯 98%

异丙醇 standard for GC，≥99.9% (GC)   氟乙酸乙酯 98%

异丙醇 for HPLC, 99.8%   氟乙酸甲酯 99%

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