10'-Desmethoxystreptonigrin
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产品名称:
10'-Desmethoxystreptonigrin
产品型号:
GOY-Y1946
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-25
简单介绍
10'-DesmethoxystreptonigrinDMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
10'-Desmethoxystreptonigrin
的详细介绍
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性能参数
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产品名称
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10'-Desmethoxystreptonigrin
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规格
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500μg 2.5mg
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货号
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GOY-Y1946
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含量
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>95.00%
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CAS
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136803-89-9
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别名
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N/A
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化学名
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N/A
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分子式
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C24H20N4O7
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分子量
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分子 476.4
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溶解度
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DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and teniposide and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 μg/ml, respectively). 10'-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM).
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