性能参数

产品名称

ATH686

规格

10mM*1 mL in DMSO 5 mg 10 mg 25 mg 50 mg

货号

GOY-Y1939

 含量

>99.00%

CAS

853299-52-2

别名

N/A

化学名

N/A

分子式

C25H28F3N7O2

分子量

分子 515.53

溶解度

DMSO : 250 mg/mL (484.94 mM; Need ultrasonic)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

ATH686 (1-100 μM; 3 days) potently inhibits cell proliferation (IC50 around 0.001 μM) via induction of apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells[1]. ATH686 (10 nM; for 15 minutes) inhibits autophosphorylation of mutant FLT3 in FLT3-ITD-Ba/F3 cells[1].

[1]. Ellen Weisberg, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32.

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