性能参数

产品名称

Ζ-Stat

规格

1mg 5mg 25mg 25mg

货号

GOY-Y1937

 含量

>99.00%

CAS

2/7/3316

别名

N/A

化学名

N/A

分子式

C10H8O10S3

分子量

分子 384.36

溶解度

H2O : 62.5 mg/mL (162.61 mM; Need ultrasonic)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].ζ-Stat (7 or 10 μM; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1].

[1]. Ratnayake WS, et, al. Oncogenic PKC-Ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-Ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. [2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

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